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Catching Dysgeusia after a COVID-19 Infection

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By Josh Piers - June 06, 2022 - 5 Mins Read

Medications

Antibiotics, Parkinson's disease drugs, epilepsy treatment, and HIV medications all have a recognized adverse effect of dysgeusia. [caption id="attachment_11023" align="aligncenter" width="746"] Paxlovid continues to be recommended for early stage treatment of mild to moderate COVID-19 among persons at high risk for progression to severe disease.[/caption] This could be due to a variety of factors. The drugs themselves may have a bitter taste that lingers in our mouths. Medications can also stimulate taste receptors that perceive bitter, sour, or metallic flavors in ways that we don't usually experience with food. Paxlovid, an antiviral medicine, is over 90% effective in lowering COVID-19 hospitalizations and deaths. Dysgeusia, on the other hand, is a common Paxlovid adverse effect. Dysgeusia is known as "Paxlovid mouth" since it affects less than 6% of the population. The drug's brand name is Paxlovid. It consists of two drugs: nirmatrelvir and ritonavir. Nirmatrelvir is the primary antiviral medicine used to treat COVID-19, and it is combined with ritonavir to prevent nirmatrelvir from being broken down too quickly, allowing it to stay active in the body for longer. When used alone or in combination with other drugs, ritonavir has a bitter taste and induces dysgeusia. Despite the lack of research into the mechanism, ritonavir could be the cause of Paxlovid mouth.